Platelet proteome changes associated with diabetes and during platelet storage for transfusion.

@article{Springer2009PlateletPC,
  title={Platelet proteome changes associated with diabetes and during platelet storage for transfusion.},
  author={D. L. Springer and John J. H. Miller and Sherry L. Spinelli and Ljiljana Pasa-Tolic and Samuel O. Purvine and Donald S Daly and Richard C. Zangar and Shuangshuang Jin and Neil Blumberg and Charles W. Francis and Mark B. Taubman and Ann E. Casey and Steven D. Wittlin and Richard P Phipps},
  journal={Journal of proteome research},
  year={2009},
  volume={8 5},
  pages={2261-72}
}
Human platelets play a key role in hemostasis and thrombosis and have recently emerged as key regulators of inflammation. Platelets stored for transfusion produce pro-thrombotic and pro-inflammatory mediators implicated in adverse transfusion reactions. Correspondingly, these mediators are central players in pathological conditions including cardiovascular disease, the major cause of death in diabetics. In view of this, a mass spectrometry based proteomics study was performed on platelets… CONTINUE READING

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