Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.

@article{Koenigsberg2012PlateletPK,
  title={Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.},
  author={Harold W. Koenigsberg and Peixiong Yuan and George A Diaz and Stephanie Guerreri and Christine Dorantes and Sarahjo Mayson and Constantin B. Zamfirescu and Antonia S. New and Marianne S. Goodman and Husseini K. Manji and Larry J. Siever},
  journal={Psychiatry research},
  year={2012},
  volume={199 2},
  pages={92-7}
}
Borderline personality disorder (BPD) is a prevalent and difficult to treat psychiatric condition characterized by abrupt mood swings, intense anger and depression, unstable interpersonal relationships, impulsive self-destructive behavior and a suicide rate of approximately 10%. Possible underlying molecular dysregulations in BPD have not been well explored. Protein kinase C (PKC) and brain-derived neurotrophic factor (BDNF) have both been implicated in affective disorders, but their role in… CONTINUE READING