Platelet production from induced pluripotent stem cells.

  title={Platelet production from induced pluripotent stem cells.},
  author={Naoshi Sugimoto and Koji Eto},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={15 9},
Ex vivo production of human platelets has been pursued as an alternative measure to resolve limitations in the supply and safety of current platelet transfusion products. To this end, induced pluripotent stem cells (iPSCs) are considered an ideal global source, as they are not only pluripotent and self-renewing, but are also available from basically any person, have relatively few ethical issues, and are easy to manipulate. From human iPSCs, megakaryocyte (MK) lines with robust proliferation… CONTINUE READING
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