Platelet-mimicry of cancer cells: epiphenomenon with clinical significance.

@article{Tmr2005PlateletmimicryOC,
  title={Platelet-mimicry of cancer cells: epiphenomenon with clinical significance.},
  author={J{\'o}zsef T{\'i}m{\'a}r and J{\'o}zsef T{\'o}v{\'a}ri and E. F. Gandolfo Raso and L{\'i}via S M{\'e}sz{\'a}ros and B{\'i}borka Bereczky and K{\'a}roly Lapis},
  journal={Oncology},
  year={2005},
  volume={69 3},
  pages={185-201}
}
Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-phenotype closely resembling the platelets and express several megakaryocytic genes (adhesion receptors alpha IIb beta 3, thrombin receptor and PECAM/CD 31 and/or platelet-type 12… CONTINUE READING