Platelet microparticles reprogram macrophage gene expression and function.

@article{Laffont2016PlateletMR,
  title={Platelet microparticles reprogram macrophage gene expression and function.},
  author={Beno{\^i}t Laffont and Aur{\'e}lie Corduan and Matthieu Rousseau and Anne-Claire Duchez and Chan Ho C Lee and Eric Boilard and Patrick Provost},
  journal={Thrombosis and haemostasis},
  year={2016},
  volume={115 2},
  pages={311-23}
}
Platelet microparticles (MPs) represent the most abundant MPs subtype in the circulation, and can mediate intercellular communication through delivery of bioactives molecules, such as cytokines, proteins, lipids and RNAs. Here, we show that platelet MPs can be internalised by primary human macrophages and deliver functional miR-126-3p. The increase in macrophage miR-126-3p levels was not prevented by actinomycin D, suggesting that it was not due to de novo gene transcription. Platelet MPs dose… CONTINUE READING
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