Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin.

@article{Raturi2008PlateletMP,
  title={Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin.},
  author={Arun Raturi and Shane Miersch and John W. Hudson and Bulent Mutus},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 12},
  pages={2790-6}
}
Platelet-derived microparticles (pMP) have been shown to be pro-aggregatory and retain most of their platelet membrane markers. Recent studies have correlated elevated pMP levels with pathogenesis of diabetes mellitus and cardiovascular disease. The pro-aggregatory effect of pMP has been largely attributed to their negatively charged outer surface and activation of factor X by membrane associated Tissue factor (TF). Here we sought to investigate whether, like platelets, protein disulfide… CONTINUE READING
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