Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers.

@article{Chomyn1994PlateletmediatedTO,
  title={Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers.},
  author={Anne Chomyn and Susan Lai and Rebecca M. Shakeley and Nereo Bresolin and G. Scarlato and Giuseppe M. Attardi},
  journal={American journal of human genetics},
  year={1994},
  volume={54 6},
  pages={966-74}
}
In the present work, we demonstrate the possibility of using human blood platelets as mitochondrial donors for the repopulation of mtDNA-less (rho 0) cells. The noninvasive nature of platelet isolation, combined with the prolonged viability of platelet mitochondria and the simplicity and efficiency of the mitochondria-transfer procedure, has substantially increased the applicability of the rho 0 cell transformation approach for mitochondrial genetic analysis and for the study of mtDNA-linked… CONTINUE READING
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