Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion.

  title={Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion.},
  author={Mami Ishikawa and Dianne Cooper and Thiruma Valavan Arumugam and John H Zhang and Anil Nanda and Daniel Neil Granger},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={24 8},
The adhesion of both leukocytes and platelets to microvascular endothelial cells has been implicated in the pathogenesis of ischemia/reperfusion (I/R) injury in several vascular beds. The objectives of this study were to (1) assess the platelet-leukocyte-endothelial cell interactions induced in the cerebral microvasculature by middle cerebral artery occlusion (MCAO)/reperfusion, and (2) define the molecular determinants of the prothrombogenic and inflammatory responses in this model of focal I… CONTINUE READING
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