Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein.

@article{Siess2006PlateletIW,
  title={Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein.},
  author={Wolfgang Siess},
  journal={Pathophysiology of haemostasis and thrombosis},
  year={2006},
  volume={35 3-4},
  pages={292-304}
}
  • Wolfgang Siess
  • Published 2006 in Pathophysiology of haemostasis and thrombosis
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases. Mildly oxidized LDL (mox-LDL) and minimally modified LDL (mm-LDL) which escape the uptake of macrophage scavenger receptors accumulate in the atherosclerotic intima. Oxidatively modified LDL is also present within the electronegative LDL fraction in blood, which is elevated in patients at high risk for cardiovascular diseases… CONTINUE READING

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