Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study.

@article{Arbel2013PlateletIE,
  title={Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study.},
  author={Yaron Arbel and Edo Y. Birati and Ariel Finkelstein and Amir Halkin and Hanna Kletzel and Yigal Abramowitz and Shlomo Berliner and Varda Deutsch and Itzhak Herz and Gad Keren and Shmuel Banai},
  journal={Clinical cardiology},
  year={2013},
  volume={36 6},
  pages={
          342-6
        }
}
BACKGROUND Concerns about an inhibitory effect of proton pump inhibitors (PPIs) on clopidogrel metabolism have been raised. Because the pharmacological effect of clopidogrel is dependent on genetically determined activity of the hepatic cytochrome P450 isoenzymes system, it is important to examine the interaction between different PPIs and high on-treatment platelet reactivity (HPR) after controlling for genetic variability. The aim of the study was to assess the effect of 2 PPIs and a… CONTINUE READING
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  • 2018
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