Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera.

@article{PanovaNoeva2011PlateletinducedTG,
  title={Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera.},
  author={Marina Panova-Noeva and Marina R Marchetti and Henri Maria Spronk and Laura Russo and Erika Diani and Guido Finazzi and Silvia Salmoiraghi and Alessandro Rambaldi and Tiziano Barbui and Hugo Ten Cate and Anna Falanga},
  journal={American journal of hematology},
  year={2011},
  volume={86 4},
  pages={337-42}
}
The platelet contribution to the thrombophilic state of patients with myeloproliferative neoplasms (MPNs), i.e., essential thrombocythemia (ET) and polycythemia vera (PV), remains uncertain. In this study we aimed to characterize the thrombin generation (TG) potential expressed by platelets from these subjects, compare it to normal platelets, and identify what factors might be responsible for platelet TG. In a group of 140 MPN patients (80 ET and 60 PV) and 72 healthy subjects, we measured the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…