Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).

@article{Nadar2004PlateletII,
  title={Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).},
  author={Sunil K. Nadar and Andrew D. Blann and Sridhar Kamath and D. Gareth Beevers and Gregory Y. H. Lip},
  journal={Journal of the American College of Cardiology},
  year={2004},
  volume={44 2},
  pages={
          415-22
        }
}
OBJECTIVES We sought to investigate the relationship between target organ damage (TOD) in hypertension and a prothrombotic/hypercoagulable state, using a new technique of "platelet lysis" to quantify the amount of P-selectin per platelet (pP-sel), and to correlate it with other platelet markers (e.g., mass, volume and granularity, soluble P-selectin [sP-sel], and beta-thromboglobulin [beta-TG]). BACKGROUND The increased risk of TOD in hypertension may be related to a prothrombotic… CONTINUE READING
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