Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.

@article{Gross1991PlateletHI,
  title={Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.},
  author={Peter L. Gross and Margaret Lucille Rand and Diana Barrow and Marian A. Packham},
  journal={Atherosclerosis},
  year={1991},
  volume={88 1},
  pages={
          77-86
        }
}
Hypercholesterolemia (mean plasma cholesterol: 15 mM) was induced in rabbits by the feeding of a chow diet enriched with a low amount (0.25%, w/w) of cholesterol only. Platelet size and protein content decreased significantly, but the whole blood platelet count did not change. The platelets became enriched in cholesterol, as indicated by a significant increase in the cholesterol:phospholipid molar (C/P) ratio. Specific responses of washed platelets stimulated with various agonists were studied… CONTINUE READING
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Low-density lipoproteins supply phospholipid-bound arachidonic acid for platelet eicosanoid production.

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