Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.

@article{MammadovaBach2015PlateletGV,
  title={Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.},
  author={Elmina Mammadova-Bach and V{\'e}ronique Ollivier and St{\'e}phane Loyau and Mathieu Schaff and B{\'e}n{\'e}dicte Dumont and R{\'e}mi Favier and Genevi{\`e}ve Freyburger and V{\'e}ronique Latger-Cannard and Bernhard Nieswandt and Christian Gachet and Pierre Henri Mangin and Martine Jandrot-Perrus},
  journal={Blood},
  year={2015},
  volume={126 5},
  pages={
          683-91
        }
}
Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as-yet-unidentified receptor is thought to mediate platelet interaction with fibrin. Platelet glycoprotein VI (GPVI) interacts with collagen and several other adhesive macromolecules. We evaluated the hypothesis that GPVI could be a functional platelet receptor for fibrin. Calibrated thrombin assays using… CONTINUE READING
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