Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.

@article{Yago2008PlateletGI,
  title={Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.},
  author={Tadayuki Yago and Jizhong Lou and Tao Wu and Jun Yang and Jonathan J Miner and Leslie Coburn and Jose Alejandro Poveda Lopez and Miguel A. Cruz and Jing-fei Dong and L. V. Mcintire and Rodger P McEver and Cheng Zhu},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 9},
  pages={3195-207}
}
Arterial blood flow enhances glycoprotein Ibalpha (GPIbalpha) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbalpha/vWF bonds first prolonged ("catch") and then shortened ("slip") bond lifetimes. Two type 2B vWD A1 domain mutants, R1306Q and R1450E, converted catch bonds to slip bonds by prolonging bond lifetimes… CONTINUE READING