Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects.

  title={Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects.},
  author={Paquita Nurden and Christel Poujol and Catherine Durrieu-Jais},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={19 12},
Glycoprotein IIb/IIIa (GPIIb-IIIa) complexes (integrin aIIbb3) mediate platelet aggregation by binding fibrinogen or von Willebrand factor (vWF), protein cofactors that form bridges between adjacent platelets. The cross-linked adhesive proteins assemble platelets into the aggregate. Agents that block the function of the GPIIb-IIIa complex of platelets constitute a powerful new generation of antithrombotic drugs. 1 Among the shortand long-term aims of such drugs are (1) to provide immediate… CONTINUE READING