Platelet glutamate and aspartate uptake in Huntington's disease.

  title={Platelet glutamate and aspartate uptake in Huntington's disease.},
  author={Richard M. Mangano and Robert M. Schwarcz},
  journal={Journal of neurochemistry},
  volume={37 4},
A possible involvement of amino acid uptake mechanisms in the etiology of the human neurodegenerative disease, Huntington's disease (HD), was investigated. Measurement of glutamate (Glu) and aspartate (Asp) uptake was performed in blood platelets, which have previously been shown to constitute a peripheral model system for central amino acid uptake processes. Analyses of Glu and Asp accumulation at 10(-7) M and kinetic examination of the high affinity site for Glu indicate no significant… CONTINUE READING