Platelet function in hypertension.

  title={Platelet function in hypertension.},
  author={Mohammed El Haouari and Juan Antonio Rosado},
  journal={Blood cells, molecules & diseases},
  volume={42 1},
Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca(2+) concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca(2+) mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new… CONTINUE READING


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