Platelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunities.

@article{Ferroni2012PlateletFI,
  title={Platelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunities.},
  author={P. Ferroni and N. Vazzana and S. Riondino and C. Cuccurullo and F. Guadagni and G. Davı̀},
  journal={Antioxidants \& redox signaling},
  year={2012},
  volume={17 10},
  pages={
          1447-85
        }
}
Increased oxidative stress appears to be of fundamental importance in the pathogenesis and development of several disease processes. Indeed, it is well known that reactive oxygen species (ROS) exert critical regulatory functions within the vascular wall, and it is, therefore, plausible that platelets represent a relevant target for their action. Platelet activation cascade (including receptor-mediated tethering to the endothelium, rolling, firm adhesion, aggregation, and thrombus formation) is… Expand
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