Platelet function in beta-thalassaemia major.

  title={Platelet function in beta-thalassaemia major.},
  author={M. Arshad Hussain and Ronald A Hutton and O Pavlidou and Allan Victor Hoffbrand},
  journal={Journal of clinical pathology},
  volume={32 5},
Abnormal platelet aggregation was found in eight (44%) of 18 patients with beta-thalassaemia major and transfusional iron overload. The aggregation defect bore no correlation with the degree of hepatic fibrosis, liver function tests, whether or not splenectomy had been performed, the degree of iron overload, haematocrit, platelet count, serum vitamin E level, or leucocyte ascorbate concentration. Only three of the 18 patients showed prolonged bleeding times as well as abnormal platelet… CONTINUE READING
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