Platelet function alterations in dengue are associated with plasma leakage.

@article{Michels2014PlateletFA,
  title={Platelet function alterations in dengue are associated with plasma leakage.},
  author={Meta Michels and Bachti Alisjahbana and Philip G. de Groot and Agnes Rengga Indrati and Rob Fijnheer and M. Puspita and Intan Mauli Warma Dewi and Lisa van de Wijer and Eline de Boer and Mark Roest and Andre J. van der Ven and Quirijn de Mast},
  journal={Thrombosis and haemostasis},
  year={2014},
  volume={112 2},
  pages={
          352-62
        }
}
Severe dengue is characterised by thrombocytopenia, plasma leakage and bleeding. Platelets are important for preservation of endothelial integrity. We hypothesised that platelet activation with secondary platelet dysfunction contribute to plasma leakage. In adult Indonesian patients with acute dengue, we measured platelet activation status and the response to the platelet agonist TRAP using flow cytometer-based assays. Patients were monitored daily for plasma leakage by ultrasonography. Acute… 
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Increased platelet-monocyte interaction was found in the absence of platelet hyper-reactivity and activation of plasmatic coagulation in stable COPD, and future clinical evaluation of the effects of different anti-platelet drugs in COPD is warranted.
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