Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.

@article{Mart2002PlateletF4,
  title={Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.},
  author={Francesc Mart{\'i} and Esther Bertr{\'a}n and M Lluci{\`a} and E Vill{\'e}n and Matilde Peir{\'o} and Joan Garc{\'i}a and F{\'e}lix G{\'o}mez-De Rueda},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={72 3},
  pages={
          590-7
        }
}
We provide evidence that platelet factor 4 (PF4), but not the related chemokine neutrophil-activating polypeptide-2, induced highly purified human natural killer (NK) cells to produce interleukin (IL)-8 in a time- and dosage-dependent manner. This ability was retained even while PF4 was bound to heparin. PF4 increased the steady state level of IL-8 mRNA, likely implying a transcriptional effect of PF4. Stimulation of NK cells through the Fc receptor for immunoglobulin G-IIIA was found to… CONTINUE READING

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