Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.

  title={Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.},
  author={Melissa S Love and Melanie G Millholland and Satish Mishra and Swapnil R. Kulkarni and Katie B. Freeman and Wenxi Pan and Robert Kavash and Michael J. Costanzo and Hyunil Jo and Thomas J. M. Daly and Dewight R. Williams and Maria Anna Kowalska and Lawrence W. Bergman and M. Poncz and William F. DeGrado and Photini Sinnis and Richard W. Scott and Doron C. Greenbaum},
  journal={Cell host & microbe},
  volume={12 6},
Plasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites. Platelets could mediate these antimalarial effects through human defense peptides (HDPs), which exert antimicrobial effects by permeabilizing membranes. Therefore, we screened a panel of HDPs and determined that human platelet factor 4 (hPF4) kills malaria parasites inside erythrocytes by selectively lysing the parasite digestive vacuole (DV… CONTINUE READING
Highly Cited
This paper has 55 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 7 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 22 extracted citations

New insights into the protective power of platelets in malaria infection

Communicative & integrative biology • 2013
View 5 Excerpts
Highly Influenced

Systematic Review: Insight into Antimalarial Peptide

International Journal of Peptide Research and Therapeutics • 2016
View 1 Excerpt

56 Citations

Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…