Platelet endothelial cell adhesion molecule in cell signaling and thrombosis

  title={Platelet endothelial cell adhesion molecule in cell signaling and thrombosis},
  author={Nanling Gong and Subroto Chatterjee},
  journal={Molecular and Cellular Biochemistry},
Platelet endothelial cell adhesion molecule (PECAM-1) is a member of the superfamily of immunoglobulins. This cell adhesion molecule has been implicated to mediate the adhesion and trans-endothelial migration of T lymphocytes/monocytes into the vascular wall, a critical step in the initiation of atherogenesis. Current thinking, however, posits that PECAM-1 by virtue of being a scaffolding molecule may well play a role in several signal transduction reactions. As a consequence, this cell… CONTINUE READING


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