Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean.

@article{Wei2004PlateletendothelialCA,
  title={Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean.},
  author={Heming Wei and L F Fang and Sanual H Chowdhury and Nanling Gong and Zhuowei Xiong and Jie Song and Koon Hou Mak and Saizhu Wu and Evelyn S.C. Koay and Sunit Sethi and Yean Leng Lim and Subroto Chatterjee},
  journal={Clinical biochemistry},
  year={2004},
  volume={37 12},
  pages={1091-7}
}
OBJECTIVES Platelet-endothelial cell adhesion molecule-1 (PECAM-1) mediates the transendothelial migration of circulating leukocytes, a characteristic change in vascular inflammation leading to atherosclerotic plaque development. We hypothesized that genetic variation and soluble level of PECAM-1 could be associated with coronary artery disease (CAD). DESIGN AND METHODS We analyzed two single nucleotide polymorphisms (SNPs) of PECAM-1 gene C+373G (Leu125Val) at exon 3, which encodes the first… CONTINUE READING

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