Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines.

@article{Nomura2000PlateletderivedMI,
  title={Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines.},
  author={Shosaku Nomura and Akira Imamura and Masahiko Okuno and Yutaka Kamiyama and Yoshihiro Fujimura and Yuika Ikeda and Shirou Fukuhara},
  journal={Thrombosis research},
  year={2000},
  volume={98 4},
  pages={
          257-68
        }
}
We evaluated the plasma concentrations of cytokines and platelet-derived microparticles in patients with arteriosclerosis obliterans and studied the effect of cytokines on platelet-derived microparticle generation under high shear stress. Interleukin-6 levels peaked at 48 hours after vascular surgery, while thrombopoietin started to increase at 24 to 48 hours postoperatively and peaked on the seventh day. Platelet activation markers were increased in the arteriosclerosis obliterans patients… CONTINUE READING

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