Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells.

@article{Loppnow1998PlateletderivedII,
  title={Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells.},
  author={Harald Loppnow and R Bil and Stephan Hirt and Uwe Schoenbeck and Mona Herzberg and Karl Werdan and Ernst T. Rietschel and Ernst Brandt and H. D. Flad},
  journal={Blood},
  year={1998},
  volume={91 1},
  pages={134-41}
}
During vascular injury, such as observed in atherosclerosis, restenosis, vasculitides, transplantation, or sepsis, vascular smooth muscle cells (SMC) can be exposed to platelets or platelet products. Under these conditions proliferation or cytokine production of SMC stimulated by platelets or platelet products may contribute to regulation of vascular pathogenesis. Thus, we investigated interleukin-6 (IL-6) and IL-8 production as well as proliferation of SMC in response to platelets or platelet… CONTINUE READING

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