Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation.

@article{Bornfeldt1995PlateletderivedGF,
  title={Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation.},
  author={Karin E Bornfeldt and Elaine W. Raines and Lee M Graves and Michael P. Skinner and Edwin G. Krebs and Russell R. Ross},
  journal={Annals of the New York Academy of Sciences},
  year={1995},
  volume={766},
  pages={416-30}
}
Figure 2 summarizes our current interpretation of data concerning signals from the activated PDGF receptor involved in directed migration and proliferation of human arterial SMC. Binding of PDGF (PDGF-BB or PDGF-AA) causes PDGF-receptor dimerization, tyrosine autophosphorylation, and subsequent binding of several molecules containing SH2 domains to the activated receptor. Binding and activation of PLC gamma by the PDGF receptor leads to PIP2 hydrolysis, resulting in generation of diacylglycerol… CONTINUE READING
61 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Similar Papers

Loading similar papers…