Platelet-derived growth factor stimulates rapid polyphosphoinositide breakdown in fetal human fibroblasts.

Abstract

The addition of human platelet-derived growth factor (PDGF) to confluent, quiescent cultures of human diploid fibroblasts induced the rapid breakdown of cellular polyphosphoinositides. The levels of 32P-labeled phosphatidylinositol 4,5-bisphosphate (PIP2), phosphatidylinositol 4-phosphate (PIP), and phosphatidylinositol (PI) decreased by 30 to 40% within 1… (More)

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@article{Chu1985PlateletderivedGF, title={Platelet-derived growth factor stimulates rapid polyphosphoinositide breakdown in fetal human fibroblasts.}, author={S. Haihua Chu and Chris J Hoban and Albert J. Owen and Robert P. Geyer}, journal={Journal of cellular physiology}, year={1985}, volume={124 3}, pages={391-6} }