Platelet-derived growth factor stimulates formation of active p 2 lras . GTP complex in Swiss mouse 3 T 3 cells

@inproceedings{Satoh2004PlateletderivedGF,
  title={Platelet-derived growth factor stimulates formation of active p 2 lras . GTP complex in Swiss mouse 3 T 3 cells},
  author={Takaya Satoh and MASAMI ENDOt and Masato Nakafuku and SHUN NAKAMURAt and Yoshito Kaziro},
  year={2004}
}
The ras gene product (p21) is a GTP-binding protein and is thought to play an important role in signal transduction of growth and differentiation in many types of mammalian cells. The p2FGTP complex is an active conformation, as described previously for polypeptide chain elongation factors (EF-Tu and EF-G) and heterotrimeric GTPbinding proteins (G proteins). In the study reported here, we measured the amounts ofp21-bound guanine nucleotides under various conditions in the G54 cell line, a… CONTINUE READING
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