Platelet-derived growth-factor requirements for in vitro proliferation of normal and malignant mesenchymal cells.


Serum obtained by clotting whole blood contains a potent mitogen with apparent specificity for mesenchymal cells. This peptide wound-healing hormone, derived from platelets, is known as platelet-derived growth factor (PDGF). Serum obtained by clotting plasma contains no detectable growth-promoting activity for fibroblasts, and is therefore a valuable… (More)
DOI: 10.1038/bjc.1981.53


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