Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells.

@article{Cheng2014PlateletderivedGA,
  title={Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells.},
  author={Xingguo Cheng and Christopher Tsao and Victor L. Sylvia and Douglas A Cornet and Daniel P Nicolella and Todd L. Bredbenner and Robert J Christy},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 3},
  pages={1360-9}
}
In order to enhance the healing potential of an injured tendon, we have prepared a novel biomimetic aligned collagen-nanoparticle (NP) composite fiber using an electrochemical process. The aligned collagen-NP composite fiber is designed to affect the cellular activity of adipose-derived stem cells (ADSCs) through two different ways: (i) topographic cues from the alignment of collagen fibril and (ii) controlled release of platelet-derived growth factors (PDGFs) from the NPs. PDGF released from… CONTINUE READING