Platelet-derived growth factor receptors on macrovascular endothelial cells mediate relaxation via nitric oxide in rat aorta.

@article{Cunningham1992PlateletderivedGF,
  title={Platelet-derived growth factor receptors on macrovascular endothelial cells mediate relaxation via nitric oxide in rat aorta.},
  author={L D Cunningham and Peter I. Brecher and Richard Alan Cohen},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={89 3},
  pages={878-82}
}
The effects of platelet-derived growth factor (PDGF) were studied in isolated rings of rat aorta contracted submaximally to phenylephrine. The BB isoform of PDGF elicited relaxation in rings with endothelium and further contraction in rings without endothelium. Both the endothelium-dependent relaxation and endothelium-independent contraction occurred at concentrations known to induce PDGF receptor-mediated responses in cultured cells. Furthermore, the relaxation was isoform specific. This… CONTINUE READING

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