Platelet-derived growth factor receptors expressed in response to injury of differentiated vascular smooth muscle in vitro: effects on Ca2+ and growth signals.

@article{Lindqvist2001PlateletderivedGF,
  title={Platelet-derived growth factor receptors expressed in response to injury of differentiated vascular smooth muscle in vitro: effects on Ca2+ and growth signals.},
  author={Anders L\oland la Lindqvist and B. Ove Nilsson and Eva Ekblad and Per Hellstrand},
  journal={Acta physiologica Scandinavica},
  year={2001},
  volume={173 2},
  pages={175-84}
}
Vascular smooth muscle cells (VSMCs) in the intact vascular wall are differentiated for contraction, whereas the response to vascular injury involves transition towards a synthetic phenotype, with increased tendency for proliferation. Platelet-derived growth factor (PDGF) is thought to be important for this process. We investigated expression and functional coupling of PDGF receptors (PDGFRs) alpha and beta in rat tail arterial rings kept in organ culture, in order to capture early events in… CONTINUE READING

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