Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation.

@article{Keating1989PlateletderivedGF,
  title={Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation.},
  author={Mark T. Keating and C C Harryman and L T Williams},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 16},
  pages={9129-32}
}
Antibodies to phosphotyrosine were used in immunoprecipitation experiments to determine if post-translational modification of the platelet-derived growth factor (PDGF) receptor was required for the acquisition of ligand-induced tyrosine kinase activity. In intact Balb/c 3T3 fibroblasts, only the fully processed 180-kDa receptor was activated (tyrosine-phosphorylated) by PDGF. In a cell-free assay, however, the tyrosine-phosphorylated forms of the 160- and 145-kDa PDGF receptor precursors were… CONTINUE READING