Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction

  title={Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction},
  author={M. Hunziker and A. O'donnell and P. Puri},
  journal={Pediatric Research},
Background:Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Normal ureteral motility requires coordinated interaction between neurons, smooth muscle cells (SMCs), and interstitial Cajal-like cells (IC-LCs). Recently, a new type of interstitial cell, platelet-derived growth factor receptor α-positive (PDGFRα+) cells, was discovered in the gastrointestinal tract and bladder.MethodsWe used immunohistochemistry to study PDGFRα protein distribution in… Expand
Identification and classification of interstitial cells in the mouse renal pelvis
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c-Kit-negative fibroblast-like cells express platelet-derived growth factor receptor α in the murine gastrointestinal musculature
Platelet-derived growth factor receptor α-positive cells in the tunica muscularis of human colon
Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells
Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
Identification of PDGFRα positive populations of interstitial cells in human and guinea pig bladders.
Differential expression of genes related to purinergic signaling in smooth muscle cells, PDGFRα‐positive cells, and interstitial cells of Cajal in the murine colon
Interstitial cells: regulators of smooth muscle function.
Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells