Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

@article{Plate1992PlateletderivedGF,
  title={Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.},
  author={Karl Heinz Plate and Georg Breier and Catherine L. Farrell and Werner Risau},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={67 4},
  pages={529-34}
}
BACKGROUND Endothelial cells proliferate during brain development, are quiescent in normal adult brain but proliferate again under pathologic conditions such as glioma growth. The vascular phenotype of low grade glioma is comparable to normal brain, however high grade gliomas are focally highly vascularized and there is associated prominent endothelial cell proliferation. The mechanisms of this change in vascular phenotype are unknown but there is evidence that growth factors play an important… CONTINUE READING

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