Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.

@article{Magnusson2007PlateletderivedGF,
  title={Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.},
  author={Peetra U Magnusson and Camilla Looman and Aive {\AA}hgren and Yan Wu and Lena Claesson-Welsh and Rainer Heuchel},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 10},
  pages={2142-9}
}
OBJECTIVE Knockout studies have demonstrated crucial roles for the platelet-derived growth factor-B and its cognate receptor, platelet-derived growth factor receptor-beta (PDGFR-beta), in blood vessel maturation, that is, the coverage of newly formed vessels with mural cells/pericytes. This study describes the consequences of a constitutively activating mutation of the PDGFR-beta (Pdgfrb(D849V)) introduced into embryonic stem cells with respect to vasculogenesis/angiogenesis in vitro and in… CONTINUE READING

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