Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.

@article{Rolny2006PlateletderivedGF,
  title={Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.},
  author={Charlotte Rolny and Ingrid Nilsson and Peetra U Magnusson and Annika Armulik and Lars Jakobsson and Parri Wentzel and Per Henrik Lindblom and Jenny M. Norlin and Christer Betsholtz and Rainer Heuchel and Michael Welsh and Lena Claesson-Welsh},
  journal={Blood},
  year={2006},
  volume={108 6},
  pages={
          1877-86
        }
}
Platelet-derived growth factor BB (PDGF-BB) has been assigned a critical role in vascular stability by promoting the recruitment of PDGF receptor-beta-expressing perivascular cells. Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-beta based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse yolk sac (embryonic day 8 [E8]) and differentiating mouse embryonic stem cells (embryoid bodies… CONTINUE READING

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