Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in Merkel cell carcinoma: implications for treatment with imatinib mesylate.

@article{Swick2008PlateletderivedGF,
  title={Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in Merkel cell carcinoma: implications for treatment with imatinib mesylate.},
  author={Brian L. Swick and Larisa Ravdel and James E. Fitzpatrick and William A. Robinson},
  journal={Journal of cutaneous pathology},
  year={2008},
  volume={35 2},
  pages={197-202}
}
BACKGROUND It is not known if Merkel cell carcinomas (MCCs) show mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene similar to a subset of gastrointestinal stromal cell tumors. The purpose of this study was to analyze MCCs for mutations in the PDGFRA gene as well as to analyze those MCCs exhibiting a possible mutation in the PDGFRA gene for immunohistochemical expression of PDGFRA. METHODS We extracted tumor DNA from nine MCCs, performed polymerase chain reaction… CONTINUE READING

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Merkel cell carcinoma. A review.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia • 2012

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