Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.

@article{Kurahashi2014PlateletderivedGF,
  title={Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.},
  author={Masaaki Kurahashi and Violeta N Mutafova-Yambolieva and Sang Don Koh and Kenton M. Sanders},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={307 6},
  pages={
          C561-70
        }
}
Enteric inhibitory neurotransmission is an important feature of the neural regulation of gastrointestinal motility. Purinergic neurotransmission, via P2Y1 receptors, mediates one phase of inhibitory neural control. For decades, ATP has been assumed to be the purinergic neurotransmitter and smooth muscle cells (SMCs) have been considered the primary targets for inhibitory neurotransmission. Recent experiments have cast doubt on both of these assumptions and suggested that another cell type… CONTINUE READING
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