Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.

  title={Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.},
  author={R E Board and Gordon C. Jayson},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={8 1-2},
Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, by overexpression or overactivation of PDGFRs, or by stimulation of angiogenesis within the tumor. These mechanisms could provide possible therapeutic targets. PDGFR blockade may also lower the interstitial fluid… CONTINUE READING