Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy.

@article{Andrews1999PlateletderivedGF,
  title={Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy.},
  author={Anne Marie Andrews and Egle Balciunaite and Frederick T L Leong and Michelle Diane Tallquist and Philippe Soriano and M. F. Alvarez Refojo and Algirdas Kazlauskas},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 11},
  pages={
          2683-9
        }
}
PURPOSE The action of growth factors is thought to make a substantial contribution to the events leading to proliferative vitreoretinopathy (PVR). In this study, the importance of platelet-derived growth factor (PDGF) was tested in a rabbit model of PVR. METHODS The approach was to compare the extent of PVR induced by cells that do or do not express the receptors for PDGF and therefore differ in their ability to respond to PDGF. RESULTS Mouse embryo fibroblasts derived from PDGF receptor… CONTINUE READING

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