Platelet-derived growth factor is released into the coronary circulation after coronary spasm.


BACKGROUND Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells and is implicated in the vascular response to injury and the pathogenesis of atherosclerosis. It is also a potent vasoconstrictor. METHODS To examine whether acute myocardial ischemia increases the level of PDGF in the coronary circulation, we measured… (More)


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