Platelet-derived growth factor is mitogenic for O-2Aadult progenitor cells.

  title={Platelet-derived growth factor is mitogenic for O-2Aadult progenitor cells.},
  author={Guus Wolswijk and Peter N. Riddle and Mark Noble},
  volume={4 5},
We report that platelet-derived growth factor (PDGF) is a potent mitogen for oligodendrocyte type-2 astrocyte (O-2A) progenitor cells derived from the optic nerves of adult rats. Moreover, O-2Aadult progenitors cultured in PDGF express the range of properties we have described previously for O-2Aadult progenitors cultured in the presence of type-1 astrocytes. Similarly, previous studies have demonstrated that PDGF is able to mimic the influence of type-1 astrocytes on O-2Aperinatal progenitors… CONTINUE READING
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