Platelet-derived growth factor enhancement of a mineral-collagen bone substitute.

  title={Platelet-derived growth factor enhancement of a mineral-collagen bone substitute.},
  author={Elaine Stephan and Rahul Renjen and Samuel Lynch and Rosemary Dziak},
  journal={Journal of periodontology},
  volume={71 12},
BACKGROUND Anorganic bovine bone-collagen matrix is commercially available for bone regeneration procedures. Platelet-derived growth factor-BB (PDGF-BB) has been demonstrated to stimulate bone formation in vivo and in vitro. It was the aim of these studies to examine 1) the interaction of this mineral-collagen matrix with PDGF-BB and 2) determine if the adsorption of PDGF-BB to the mineral-collagen matrix stimulates osteoblastic cell proliferation above that of the untreated matrix. METHODS… CONTINUE READING
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