Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements.

@article{Wang1994PlateletderivedGF,
  title={Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements.},
  author={Conrad Wang and Charles Dean Stiles},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 15},
  pages={7061-5}
}
Receptors for the platelet-derived growth factors (PDGFs) are expressed conditionally in developing embryos and adult tissues. Aberrant expression of PDGF receptors is a molecular marker for proliferative disorders such as atherosclerosis, myofibrosis, and malignant astrocytoma. We isolated genomic clones that encompass the 5' end of the mouse PDGF alpha receptor mRNA transcript and extend 10 kb into the upstream flanking region of the gene. Using these clones, we constructed a partial genomic… CONTINUE READING
7 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…