Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.

@article{Cadamuro2013PlateletderivedGF,
  title={Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.},
  author={Massimiliano Cadamuro and Giorgia Nardo and Stefano Indraccolo and Luigi Dall'olmo and Luisa Sambado and Lidia Moserle and Irene Franceschet and Michele Colledan and M Massani and Tommaso Stecca and Nicol{\'o} Bassi and Stuart Duncan Morton and Carlo Spirl{\'i} and Romina Fiorotto and Luca Fabris and Mario Strazzabosco},
  journal={Hepatology},
  year={2013},
  volume={58 3},
  pages={
          1042-53
        }
}
UNLABELLED Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer-associated fibroblasts (CAFs) are pivotal in tumor growth and invasiveness and represent a potential therapeutic target. To understand the mechanisms leading to CAF recruitment in CCA, we studied (1) expression of epithelial-mesenchymal transition (EMT) in surgical CCA specimens and CCA cells, (2) lineage tracking of an enhanced green fluorescent protein (EGFP)-expressing human male CCA cell line (EGI-1… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.

  • Biochimica et biophysica acta. Molecular basis of disease
  • 2017
VIEW 11 EXCERPTS
CITES BACKGROUND

Pathogenesis, diagnosis, and management of cholangiocarcinoma.

  • Gastroenterology
  • 2013
VIEW 19 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.

  • Annual review of pathology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Emerging roles of PDGF-D signaling pathway in tumor development and progression.

  • Biochimica et biophysica acta
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.

  • Liver international : official journal of the International Association for the Study of the Liver
  • 2004
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2012
VIEW 1 EXCERPT