Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.

@article{Fredriksson2012PlateletderivedGF,
  title={Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.},
  author={Linda Fredriksson and Ingrid Nilsson and Enming Joseph Su and Johanna Andrae and Hao Ding and Christer Betsholtz and Ulf Eriksson and Daniel A Lawrence},
  journal={The American journal of pathology},
  year={2012},
  volume={180 3},
  pages={1136-44}
}
Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) are known to play important roles during development of the lungs, central nervous system (CNS), and skeleton and in several diseases. PDGF-C is a ligand for the tyrosine kinase receptor PDGFRα. Mutations in the gene encoding PDGF-C have been linked to clefts of the lip and/or palate in humans, and ablation of PDGF-C in 129/Sv background mice results in death during the perinatal period. In this study, we… CONTINUE READING

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