Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species.

@article{Lange2009PlateletderivedGF,
  title={Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species.},
  author={Sabine Lange and Jaqueline Heger and Gerhild Euler and Maria Wartenberg and Hans Michael Piper and Heinrich Sauer},
  journal={Cardiovascular research},
  year={2009},
  volume={81 1},
  pages={
          159-68
        }
}
AIMS Platelet-derived growth factor BB (PDGF-BB) has been assigned a critical role in vascular growth and recruitment of perivascular mural cells. The purpose of the present study is to investigate the signalling events underlying the stimulation of vasculogenesis of mouse embryonic stem (ES) cells by PDGF-BB. METHODS AND RESULTS PDGF-BB increased vascular sprouting and branching of capillary-like structures in embryoid bodies as evaluated by computer-assisted analysis of CD31-positive cell… CONTINUE READING

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